Technically speaking, to have the least amount of noise in your setup, covering the distance from the Ultra to your speakers, the preferred connections would be in the following order:
USB > Optical > RCA out (analog)
Using either USB or optical, you allow the signal to be transferred digitally to your speakers (without interference) and use the speakers' built-in DAC (which is probably finetuned and nicely implemented into to your speakers' amplifier circuit)
However, it might as well be the case that the Ultra's DAC is superior to the built-in DAC of the speakers or simply that you prefer the overall sound & character of the Ultra's DAC, connected over RCA.
This raises another question though: how do the Klipsch handle the line-input? Is it digitised or sent directly to the amplification circuit?