I have personally found USB to work flawlessly, whereas I had signal integrity issues (mid-track pops/noises) with both, optical and coax S/PDIF outputs. It was not a problem with the inputs on my DAC because inserting a USB DDC after the WiiM and then using either optical or coax S/PDIF outputs from the DDC to the DAC eliminated the problem, so I specifically blame the those two outputs on the WiiM Ultra. I also ruled out cables because I rolled numerous completely different optical as well as coax cables to no avail.
-Ed